Starting a new school year, Squish, a meek amoeba who loves the comic book exploits of his favorite hero, "Super Amoeba," is determined to get picked for kickball and hang out with the cool kids.

Squish, comic book fan and grade school amoeba, is made captain of his soccer team and following the example of his favorite superhero, must, figure out how to turn a losing streak around without losing his friends.

Afraid to watch horror movies with his friend, Pod, Squish the amoeba feels better after learning that even comic book superheroes get scared sometimes.

Squish the amoeba's friend Pod has been feeling strange lately, but Squish finds out Pod is going through mitosis, the process that splits single-celled organisms.