Mrs. Piggle-Wiggle lives in an upside-down house and smells like cookies. She was even married to a pirate once. Most of all, she knows everything about children and can cure them of any ailment. Patsy hates baths. Hubert never puts anything away. Allen eats v-e-r-y slowly. Mrs. Piggle-Wiggle has a treatment for all of them.

Mrs. Piggle-Wiggle is back with special cures for the not truthful, the pet forgetter, the fraidy-cat, the destructive child, and the child who continually says, "I can't find it."

As the children plan a birthday party for Mrs. Piggle-Wiggle, the loveable problem solver offers cures for such common conditions as watching too much television and the fear of trying new things.